Assistant Professor in the field of Physics
Dr. Nihar Ranjan Jena received his PhD degree from Banaras Hindu University (BHU), India in 2006. Subsequently, he did his Postdoctoral from the Hebrew University of Jerusalem, Jerusalem, Israel, and National Taiwan Normal University, Taipei, Taiwan. He has also worked as a Guest Scientist in the German Cancer Research Center (DKFZ), Heidelberg, Germany, and a research scientist in the Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India. He is also a recipient of the Indo-Australia visiting fellowship (2013-2014) from the Indian National Science Academy, which was availed in the University of Queensland, Australia. Currently, he is working as an Assistant Professor in Physics at the PDPM-Indian Institute of Information Technology Design and Manufacturing Jabalpur, India.
Artificial DNA, Biosensors, Drug design, DNA-Protein interactions, Enzymatic catalysis.
Banaras Hindu University
- - Research Scientist
Molecular Biophysics Unit, Indian Institute of Science, Bangalore
- - Visiting Academic
University of Queensland, Australia
- - Research scientist
Indian Institute of Science, Bangalore, India
- - Lecturer
Ravenshaw University, Cuttack, Odisha
- - Postdoc
National Taiwan Normal University, Taiwan
- - Guest scientist
DKFZ (German Cancer Research Centre), Germany
- - Postdoc
Hebrew University of Jerusalem, Israel
- - Member of the IWD Tender Committee
- - Member of Central Purchase Committee
- - Warden, Hall-III
- Senior Research Fellowship Award from the Council of Scientific and Industrial Research
- International Travel Award from DST
- Late Shri Harbansh Singh Memorial Best Young Scientist Award by Laser & Spectroscopy Society of India
- Young Scientist Award from Indian Science Congress
- Visiting Academic at the University of Queensland, Australia
School of Chemistry and Molecular Biosciences, University of Queensland, Australia
Current & Previous
|Course Code||Course name||Category||Institute|
Areas or Specialisation / Project Activities / Publications / Books
- Understanding of DNA Damage and Repair by Enzyme Residues.
DST-sponsored project. Funds Approved: ~ Rs 14,00000 Tenure: 2009-2012
- Computational Design of Functional Nucleotides for Artificial Life.
SERB-sponsored project. Funds approved: Rs 50,00160 Tenure: 2017-2020
- Mechanisms of Activation of Type I Cytokine Receptors.
Indian National Science Academy (as a part of Indo-Australia S&T programme), Funds approved: ~Rs 20,00000
- Mutational properties of DNA base Lesions.
IIITDM Jabalpur, Funds approved: ~10,00000
- Discovery of Therapeutic Candidates for the Treatment of Zika Viral Infection by using Advanced Computational Techniques
CSIR-sponsored project. Funds approved: Rs 17,84000 Tenure: 2021-2024
- Design and Development of Biosensors for the Early Diagnosis of Cancer and Other Diseases
DIC-sponsored project. Funds approved: Rs 13,00000 Project surrendered
- A Few Selected Publications:
S. Pant, G. Bhattacharya, N.R. Jena* (2022) Structures and dynamics of peptide and peptidomimetic inhibitors bound to the NS2B-NS3 protease of the ZIKA virus. J. Biomol. Struct. Dyn. DOI: 10.1080/07391102.2022.2045223
N.R. Jena* (2022) Rare tautomers of artificially expanded genetic letters and their effects on the base pair stabilities . ChemPhysChem, DOI: 10.1002/cphc.202100908
N. R. Jena* & P. Das (2021): Hybrid nucleobases as new and efficient unnatural genetic letters, J. Biomol. Struct. Dyn., DOI: 10.1080/07391102.2021.2003863.
Suyash Pant, N.R. Jena*, (2021) Inhibition of the RNA-dependent RNA polymerase of SARS-CoV-2 by Short Peptides, Eur. J. Pharm. Sci. 167, 106012.
N.R. Jena*, (2021) Drug Targets and Therapeutics against SARS-CoV-2, Chemical Physics Impact 2, 100011.
N.R. Jena*, Suyash Pant, Hemant Kumar Srivastava, (2021) Artificially Expanded Genetic Information Systems as Potent Inhibitors of the RNA-dependent RNA polymerase of SARS-CoV-2. J. Biomol. Struct. Dyn. 1-17, doi: 10.1080/07391102.2021.1883112.
N.R. Jena, (2020) Role of Different Tautomers on the Base-Pairing Abilities of Some of the Vital Antiviral Drugs used Against COVID-19. Phys. Chem. Chem. Phys., 22, 28115-28122.
N.R. Jena* (2020) Identification of Potent Drugs and Antiviral Agents for the Treatment of the SARS-CoV-2 Infection. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.12330599.v1
N.R. Jena*, (2020) Electron and Hole Interactions with P, Z, and P:Z and the Formations of Mutagenic Products by Proton Transfer Reactions, Phys. Chem. Chem. Phys. 22, 919-931.
B. Behera, P. Das, N.R. Jena* (2019) Accurate Base Pair Energies of Artificial Genetic Alphabets: Clues for Their Mutagenic Characteristics. J. Phys. Chem. B 123, 31, 6728-6739.
N.R. Jena*, (2019) Manganese Coordinated Tyrosine Bio Materials for the Sensing of Reactive Oxygen Species. ChemistrySelect 4, 6945-6953.
N.R. Jena*, C. Patel, S.C. Sahoo, P.C. Mishra (2018), Cysteine-metal Porous Frameworks as Biosensing Elements for the Adsorption of Reactive Oxygen Species., ChemistrySelect 3, 7732-7740.
N.R. Jena*, P. Das, B. Behera, P.C. Mishra, (2018) Analogues of P and Z as Efficient Artificially Expanded Genetic Information System., J. Phys. Chem. B., 34, 8134-8145.
M.K. Tiwari, N.R. Jena, P.C. Mishra (2018), Mechanisms of Scavenging Superoxide, Hydroxyl, Nitrogen Dioxide and Methoxy Radicals by Allicin: Catalytic Role of Superoxide Dismutase in Scavenging Superoxide Radical. J. Chem. Sci., 130, 105.
N.R. Jena*, P.C. Mishra (2016) Normal and Reverse Base Pairs of Iz and Oz Lesions in DNA: Structural Implications for Mutagenesis, RSC Advances, 6, 64019-64027.
N.R. Jena*, Manju Bansal, P.C. Mishra (2016) Conformational Stabilities of Iminoallantoin and its Base Pairs in DNA: Implications for Mutagenicity, Physical Chemistry Chemical Physics, 18, 12774-12783.
N.R. Jena*, V. Gaur, P.C. Mishra (2015) The R-and S-diastereoisomeric Effects on the Guanidinohydantoin-induced Mutations in DNA, Phys. Chem. Chem. Phys. 17, 8111-18120.
N.R. Jena*, A.E. Mark, P.C. Mishra (2014) Does Tautomerization of FapyG Influence its Mutagenicity? ChemPhysChem, 15, 1779-1784.
N.R. Jena*, P.C. Mishra (2013) Is FapyG Mutagenic? Evidence from the DFT Study. ChemPhysChem 14, 3263-3270.
N.R. Jena* (2012) DNA Damage by Reactive Species: Mechanisms, Mutation and Repair. J. Biosci. 37, 503-517.
N.R. Jena*, P.C. Mishra (2012) Formation of Ring-opened and Rearranged Products of Guanine: Mechanisms and Biological Significance. Free Radic. Biol. Med. 53, 81-94.
N.R. Jena* (2012) Binding of Bis Like and Other Ligands with the GSK-3? Kinase: A Combined Docking and Molecular Dynamics Study. J. Mol. Model. 18, 631-644.
N.R. Jena*, Manju Bansal (2011) Mutagenicity Associated with O6-Methylguanine DNA Damage and Mechanism of Nucleotide Flipping by AGT During Repair. Phys. Biol. 8, 046007.
P.K. Shukla, N.R. Jena, P.C. Mishra (2011) Quantum Theoretical Study of Molecular Mechanisms of Mutation and Cancer: A review. Proc. Natl. Acad. Sc. A (India), 81A, 79-98.
N.R. Jena*, P.S. Shukla, H.S. Jena, P.C. Mishra, S. Suhai (2009) O6-Methylguanine Repair by O6-Alkylguanine Alkyl Transferase. J. Phys. Chem. B, 113, 16285-16290.
W.-H. Wang, N.R. Jena, Y.-C. Wang, Y.-C. Sun (2009) A 3D-QSAR study of Celebrex-based PDK1 Inhibitors Using CoMFA Method. J. Chin. Chem. Soc. 56, 59-64.
N.R. Jena*, P.C. Mishra, S. Suhai (2009) Protection against Radiation-Induced DNA Damage by Amino Acids: A DFT Study. J. Phys. Chem. B 113, 5633-5644.
N.R. Jena, P.C. Mishra (2009) Interactions of Guanine, Its Anions and Radicals with Lysine in Different Charge States. J. Phys. Chem. B 11, 5418-5424.
N.R. Jena, P.S. Kushwaha, P.C. Mishra (2008) Reaction of Hypochlorous Acid with Imidazole: Formation of 2-Chloro and 2-Oxoimidazoles. J. Comput. Chem. 29, 98-107.
N.R. Jena, P.C. Mishra (2007) Formation of 8-Nitroguanine and 8-Oxoguanine Due to Reactions of Peroxynitrite with Guanine. J. Comput. Chem. 28, 1321-1335.
N.R. Jena, P.C. Mishra (2007) A Theoretical Study of Some New Analogues of the Anti-Cancer Drug Camptothecine. J. Mol. Model. 13, 267-274.
N.R. Jena, P.C. Mishra (2006) Addition and Hydrogen Abstraction reactions of an OH Radical with 8-oxoguanine. Chem. Phys. Letts. 422, 417-423.
N.R. Jena, P.C. Mishra (2005) Mechanisms of Formation of 8-oxoguanine Due to Reactions of One and Two OH Radicals and the H2O2 Molecule with Guanine: A Quantum Computational Study. J. Phys. Chem. B 109, 14205-14218.
N.R. Jena, P.C. Mishra (2005) An ab-initio and Density Functional Study of Microsolvation of Carbon Dioxide in Water Clusters and Formation of Carbonic Acid. Theor. Chem. Accts. 114, 189-199.
N.R. Jena, P.C. Mishra (2005) Study of Relationship of Atomic Orbital Hybridization with Bonding Using Hybridization Displacement Charge: Optimal Hybridization Principle. J. Mol. Struct. (Theochem) 719, 75-84.
N.R. Jena, Neha Agnihotri, P.C. Mishra (2014) Formation of DNA Lesions, Its Prevention and Repair. Book Title: Computational Techniques in Pharmacy and Medicine, Springer, 59-94, edited by Leonid Gorb, Victor Kuz'min, Eugene Muratov, ISBN: 978-94-017-9257-8.
National Symposium on "Innovations in Product Design" was organized from May 11-13, 2015 at IIITDM Jabalpur.
Conferences/Symposia Grants Received: 1. Department of Biotechnology (DBT), India 2. Council of Scientific and Industrial Research (CSIR), India 3. MP Council of Science and Technology (MPCOST), India
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